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danazol will increase the degree or effect of diazepam by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Check.bosentan will lessen the extent or outcome of diazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Keep an eye on.There are lots of variables that affect how long Valium stays in the human body